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Updated: Oct 13, 2026
A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
Published on: July 17, 2012
[Cardiac rupture: histological study of ruptured and non-ruptured myocardial infarcts (author's transl)]
Insights
Myocardial infarct rupture is linked to transmural infarction and inflammation. Early death is more common with non-ruptured infarcts, while rupture occurs later, often between days 3-4.
Area of Science:
- Cardiovascular Pathology
- Histopathology
- Myocardial Infarction Research
Context:
- Histological analysis of 178 myocardial infarcts with wall rupture and 116 without.
- Investigated infarct age, rupture timing, and patient mortality.
- Examined transmural extent and inflammatory cell infiltration in ruptured infarcts.
Purpose:
- To determine the histological factors associated with myocardial infarct wall rupture.
- To compare mortality rates and infarct characteristics between ruptured and non-ruptured myocardial infarcts.
- To identify key morphological predictors of infarct rupture.
Summary:
- Mean infarct age was 3.7 days for ruptured and 2.9 days for non-ruptured cases.
- Transmural infarction (71.7%) and significant leucocytic infiltration were primary features of ruptured infarcts.
- Rupture often occurred between days 3-4, with higher early mortality (57.7%) in non-ruptured cases compared to ruptured (25.8%).
- Infarct recurrence was higher in non-ruptured (73%) versus ruptured (20%) cases.
Impact:
- Identifies transmural infarction and marked leucocytic reaction as main causes of myocardial infarct rupture.
- Provides insights into the timing of rupture and its correlation with mortality.
- Highlights differences in infarct recurrence rates based on rupture status.
Abstract:
178 myocardial infarcts with wall rupture and 116 without were studied histologically. Mean morphological age of the infarct was 3.7 in the ruptured and 2.9 days in the non-ruptured cases. 57.7% of patients had died within the first 24 hours from a non-ruptured infarct. Death rate within the first 24 hours after infarction was 57.7% among the non-ruptured cases, 25.8% among those with rupture. 23.1% of infarcts had ruptured between the third and fourth day. Only 5.1% of patients with non-ruptured infarcts had died on the third or fourth day. Transmural infarction was present in 71.7% of those that had ruptured. The ruptured channel in general ran through the middle of the necrotic-infarcted, leucocyte-infiltrated myocardium. Infarct recurrence was demonstrated in 20% of ruptured and 73% of non-ruptured infarcts. Morphological comparison indicated that transmural infarction and marked leucocytic reaction in a not previously infarct-damaged myocardium are the main causes for rupture in myocardial infarction.
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