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[Asymptomatic haematuria (author's transl)]
Deutsche Medizinische Wochenschrift (1946)
|April 18, 1980
Summary
Asymptomatic hematuria in patients often indicates underlying kidney disease, specifically mesangioproliferative glomerulonephritis. Renal biopsy is crucial for accurate diagnosis, revealing kidney pathology even with mild hematuria.
Area of Science:
- Nephrology
- Pathology
- Internal Medicine
Context:
- Asymptomatic hematuria is a common clinical finding.
- Previous diagnostic approaches may not adequately identify underlying renal pathology.
- The significance of "physiological" hematuria requires re-evaluation.
Purpose:
- To investigate the histological findings in patients presenting with asymptomatic hematuria.
- To determine the correlation between hematuria intensity and histological changes.
- To assess the diagnostic value of percutaneous renal biopsy.
Summary:
- Renal biopsy revealed mesangioproliferative glomerulonephritis in 86.2% of 130 patients with asymptomatic hematuria.
- Other findings included benign nephrosclerosis, interstitial nephritis, and perimembranous glomerulonephritis; normal parenchyma was rare (6.9%).
- Immunohistology showed IgA, IgG, and C3 complement deposits in 25.7% of cases. Hematuria intensity did not correlate with histological severity.
Impact:
- Highlights the high prevalence of significant kidney disease in asymptomatic hematuria.
- Suggests re-evaluating the definition of "physiological" hematuria.
- Supports percutaneous renal biopsy as a safe and definitive diagnostic tool, potentially avoiding unnecessary investigations.