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Comparative bioavailability of disopyramide after multiple dosing with standard capsules and controlled-release
European Journal of Clinical Pharmacology
|January 1, 1980
Summary
Standard disopyramide capsules and controlled-release tablets showed similar bioavailability. Capsules led to a faster peak plasma concentration of disopyramide compared to controlled-release tablets.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Disopyramide is an antiarrhythmic medication.
- Understanding its pharmacokinetics is crucial for effective treatment.
Purpose of the Study:
- To compare plasma concentrations and bioavailability of disopyramide from standard capsules versus controlled-release tablets.
- To assess the pharmacokinetic profiles of different disopyramide formulations.
Main Methods:
- A randomized crossover study involving ten patients.
- Administration of disopyramide capsules (150 mg every 6 h) and controlled-release tablets.
- Measurement of plasma disopyramide concentrations over time.
Main Results:
- Standard capsules resulted in a more rapid rise to peak plasma disopyramide concentrations (1.8 h) compared to controlled-release tablets (4.0 h).
- No significant differences in plasma concentration fluctuations at steady state were observed between formulations.
- The overall bioavailability of disopyramide was equivalent for both capsules and controlled-release tablets.
Conclusions:
- Both standard capsules and controlled-release tablets provide equivalent bioavailability of disopyramide.
- The choice of formulation may influence the rate of achieving peak plasma concentrations.
- Further research could explore the clinical implications of differing absorption rates.