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Vitelliform lesions associated with retinal pigment epithelial detachment
Annals of Ophthalmology
|December 1, 1978
Summary
Normal electro-oculogram results in two patients with vitelliform macular lesions suggest a different cause. Retinal pigment epithelial detachment with subpigmentary material can mimic Best
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Best's disease, a hereditary macular dystrophy, is characterized by vitelliform lesions.
- Electro-oculogram (EOG) is a diagnostic test used in assessing retinal function.
Observation:
- Two patients presented with bilateral vitelliform macular lesions.
- These patients exhibited normal electro-oculogram (EOG) findings.
- Fluorescein angiography revealed retinal pigment epithelial detachment in both cases.
Findings:
- The study identified retinal pigment epithelial detachment with subpigment epithelial lipid and/or protein accumulation.
- This finding represents an alternative mechanism for developing lesions resembling classical Best's disease.
Implications:
- This expands the differential diagnosis for vitelliform macular lesions.
- It highlights the importance of considering retinal pigment epithelial detachment in cases with atypical EOG results.
- Further research may elucidate the specific role of subpigmentary material in macular pathology.