[Effect of lysozyme suppression of factor XII activation on postadrenaline hypercoagulation]

Adrenaline administration (0.5 mg/kg) in rabbits shortened the blood clotting time for about 30 min, whereas under the lysozyme effect no shortening occurred. I. v. lysozyme administration (0.05 mg/kg) induced clear though transitory decrease of total and latent BAEE-esterase activity of the blood plasma. The data obtained emphasize the role of factor XII activation by adrenaline for physiological regulation of blood coagulability.