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[Functional morphology of the parietal cells]
Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova
|February 1, 1980
Summary
Histamine triggers two distinct stomach acid secretion patterns in ground squirrels. Electron microscopy revealed unique parietal cell changes, including endocytosis during abrupt acid reduction.
Area of Science:
- Gastroenterology
- Cell Biology
- Physiology
Background:
- Parietal cells in the stomach lining are responsible for secreting hydrochloric acid (HCl).
- Understanding the dynamic changes in parietal cells during acid secretion is crucial for comprehending gastric function.
- Histamine is a known stimulant of gastric acid secretion.
Purpose of the Study:
- To investigate the ultrastructural changes in gastric parietal cells of Citellius erythrogenys Br. during different patterns of acid secretion.
- To correlate observed morphological changes with distinct secretory responses to histamine stimulation.
Main Methods:
- Perfused stomachs from anesthetized Citellius erythrogenys Br. were used.
- Acid secretion (HCl output) was monitored.
- Stomachs were fixed at specific secretory activity points.
- Samples were examined using electron microscopy.
Main Results:
- Two distinct patterns of HCl secretion decrease were observed following identical histamine doses: abrupt and slow.
- Characteristic morphologies of active and non-secreting parietal cells were confirmed.
- Intermediate stages of parietal cell activity were identified.
- Endocytotic membrane profiles were observed in parietal cells during abrupt decreases in HCl secretion.
Conclusions:
- Histamine can induce differential responses in gastric acid secretion, characterized by abrupt or slow decline.
- Parietal cell morphology dynamically changes, reflecting secretory states, with endocytosis playing a role in the cessation of acid secretion, particularly during abrupt responses.