Assessment of some variables affecting the blanching activity of betamethasone 17-valerate cream

The effect of concentration and occlusion time on the ability of Betnovate cream (betamethasone 17-valerate 0.1%) to produce skin blanching was assessed. Generally, increased concentration or occlusion time produce an increase in the degree of blanching observed, however, a plateau stage is eventually reached where no further increase of blanching occurs.