Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercholesterolemia and auditory dysfunction. Experimental studies

T Morizono, M M Paparella

    The Annals of Otology, Rhinology, and Laryngology
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The surgical challenge of carotid artery and Fallopian canal dehiscence in chronic ear disease: a pitfall for endoscopic approach.

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2016
    Same author

    Production of a human antibody fragment against the insulin-like growth factor І receptor as a fusion protein.

    Drug discoveries & therapeutics·2012
    Same author

    Ototoxicity of Povidone-Iodine applied to the middle ear cavity of guinea pigs.

    International journal of pediatric otorhinolaryngology·2011
    Same author

    Safety of ofloxacin (OFLX) and fosfomycin sodium (FOM) ear drops.

    International journal of pediatric otorhinolaryngology·2007
    Same author

    [Histopathologically observational study of cartilage-mucosa on the eustachian tube isthmus of temporal bone with otitis media].

    Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology·2003
    Same author

    Pattern changes of mucin gene expression with pneumococcal otitis media.

    International journal of pediatric otorhinolaryngology·2001
    Same journal

    Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Clinical and Voice Outcome Differences in Vocal Cord Cysts with and Without Sulcus Vocalis: Insights From a Tertiary Center in Saudi Arabia.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Bioabsorbable Stenting in a Case of Severe Pediatric Posterior Glottic Stenosis.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Efficacy and Safety of Finafloxacin Otic Suspension, 0.3% for the Treatment of Acute Otitis Externa: Results from two Phase III Randomized Clinical Studies.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Evaluation Of the Expression Levels Of SerpinB3/B4/B10, Interleukin-17 As Biomarkers For Chronic Rhinosinusitis With Nasal Polyps.

    The Annals of otology, rhinology, and laryngology·2026
    Same journal

    Correlation of Patient-Reported Symptoms With Rhinogram Features Beyond Simple Airway Resistance.

    The Annals of otology, rhinology, and laryngology·2026
    See all related articles

    This study in rabbits suggests that high cholesterol diets and hypertension can lead to auditory dysfunction. These conditions, when combined, appear to worsen hearing loss, particularly at higher frequencies.

    Area of Science:

    • Otorhinolaryngology
    • Cardiovascular Science
    • Metabolic Research

    Background:

    • Auditory dysfunction is a growing concern with potential links to metabolic and cardiovascular health.
    • Experimental models are crucial for understanding the mechanisms behind hearing impairment.
    • Hypertension and hypercholesterolemia are known cardiovascular risk factors with potential systemic effects.

    Purpose of the Study:

    • To investigate the long-term effects of experimental hypertension and hypercholesterolemia on auditory function in rabbits.
    • To determine if these conditions individually or in combination impact hearing thresholds.
    • To establish an animal model for studying the relationship between metabolic/cardiovascular health and hearing.

    Main Methods:

    • Rabbits were subjected to chronic implantation of electrodes in the inferior colliculus for auditory response monitoring.

    Related Experiment Videos

  • Hypertension was induced using the renal encapsulation technique.
  • Hypercholesterolemia was induced by daily feeding of cholesterol for three months.

    • Main Results:

    • Hypertension alone caused a dip in auditory function at higher frequencies and improvement at lower frequencies.
    • Cholesterol-fed rabbits exhibited progressive auditory dysfunction across all frequencies.
    • Combined hypertension and hypercholesterolemia resulted in additive auditory changes.

    Conclusions:

    • Experimental hypertension and hypercholesterolemia are associated with auditory dysfunction in rabbits.
    • The effects on auditory function appear to be additive when both conditions are present.
    • These findings suggest a link between diet-induced hypercholesterolemia and hearing impairment, warranting further investigation.