Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pharmacokinetic problems in surgery]

W Fabian, F Sörgel, E Fellmann

    Fortschritte Der Medizin
    |January 17, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib-Treated Cancer.

    CPT: pharmacometrics & systems pharmacology·2017
    Same author

    [Pharmacokinetics and pharmacodynamics of antibiotics in intensive care].

    Medizinische Klinik, Intensivmedizin und Notfallmedizin·2016
    Same author

    Blood, tissue, and intracellular concentrations of azithromycin during and after end of therapy.

    Antimicrobial agents and chemotherapy·2013
    Same author

    Blood, tissue, and intracellular concentrations of erythromycin and its metabolite anhydroerythromycin during and after therapy.

    Antimicrobial agents and chemotherapy·2011
    Same author

    Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers.

    Antimicrobial agents and chemotherapy·2011
    Same author

    Penetration of meropenem into epithelial lining fluid of patients with ventilator-associated pneumonia.

    Antimicrobial agents and chemotherapy·2011
    Same journal

    [More information--less pain. Procedure in pain following amputation of limbs. Brachial plexus injury and nerve root avulsion. Interview by Susanne Kammerer].

    Fortschritte der Medizin·1999
    Same journal

    [Galenic alternatives to unstable tocopherol acetate. "Smeared" or cheated?--Vitamin E in facial ointments].

    Fortschritte der Medizin·1999
    Same journal

    [Gene diagnosis in the hand of the physician].

    Fortschritte der Medizin·1999
    Same journal

    [Is non-toxic cancer therapy through biotechnology a possibility?].

    Fortschritte der Medizin·1999
    Same journal

    [Smoking withdrawal in practice and clinic].

    Fortschritte der Medizin·1999
    Same journal

    [The future of pancreas diagnosis. An exclusive training service of the Gastro-Ligue for dermatologists].

    Fortschritte der Medizin·1999
    See all related articles

    Pharmacokinetic models often fail to accurately predict drug tissue concentrations. Collaboration between surgeons and pharmacokinetic researchers is essential to improve these predictions and enhance drug delivery strategies.

    Area of Science:

    • Pharmacology
    • Drug Metabolism and Pharmacokinetics
    • Surgical Science

    Context:

    • Pharmacokinetic models are crucial for understanding drug behavior in the body.
    • Predicting drug concentrations at specific tissue sites remains a significant challenge.
    • Existing models often do not fully account for complex physiological factors influencing drug distribution.

    Purpose:

    • To highlight the limitations of current pharmacokinetic models in predicting tissue drug concentrations.
    • To emphasize the need for interdisciplinary collaboration to address these predictive shortcomings.
    • To present case examples demonstrating the value of integrating surgical insights into pharmacokinetic modeling.

    Summary:

    • This article discusses the inadequacies of pharmacokinetic models in forecasting drug levels within tissues.

    Related Experiment Videos

  • It presents findings from our research group illustrating that surgeon-researcher partnerships are vital.
  • These collaborations are necessary to surmount the current limitations in predictive accuracy.

    • Impact:

    • Improved accuracy in predicting drug tissue concentrations can lead to optimized dosing regimens.
    • Enhanced understanding can facilitate more effective therapeutic strategies, particularly in surgical contexts.
    • Fostering collaboration between pharmacokineticists and surgeons can advance precision medicine and patient outcomes.