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Capillary alterations in scleroderma

R Fleischmajer, J S Perlish

    Journal of the American Academy of Dermatology
    |February 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Electron microscopy revealed key capillary changes in scleroderma skin, including endothelial cell damage and basal lamina reduplication, preceding fibrosis. These findings offer insights into the microvascular pathology of scleroderma.

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    Area of Science:

    • Vascular biology
    • Dermatology
    • Pathology

    Background:

    • Scleroderma is a complex autoimmune disease characterized by fibrosis.
    • Microvascular abnormalities are implicated in scleroderma pathogenesis.

    Purpose of the Study:

    • To investigate the ultrastructural alterations of capillaries in scleroderma skin using electron microscopy.

    Main Methods:

    • Electron microscopy was employed to examine capillary structures in skin biopsies from patients with scleroderma.

    Main Results:

    • Observed alterations included endothelial cell gaps, vacuolization, and destruction.
    • Reduplication of the basal lamina and perivascular cellular infiltrates (lymphocytes, plasma cells, macrophages, monocytes) were noted.

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  • Fibroblasts and pericytes showed enlarged rough endoplasmic reticulum (RER), associated with perivascular fibrosis. Endothelial cell damage and infiltrates preceded fibrosis.

    • Conclusions:

    • The study identified significant ultrastructural capillary damage in scleroderma.
    • Endothelial cell injury and inflammatory cell infiltration appear to be early events in the development of scleroderma-associated fibrosis.