Related Experiment Video
Updated: Aug 4, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
Published on: March 13, 2013
The rampant basal-cell carcinoma: report and lessons of a case
Abstract:
The case of a patient with a basal-cell carcinoma over a clavicle that escaped early treatment and became widespreadand deeply burrowing is recounted. It was first treated by radiotherapy, seemed to have been cured thereby, but two years later showed recurrence. It was then treated by Mohs' fresh-tissue technique which cleared the skin but exposed invaded bone and uncertain depth of involvement below. Radical extirpative surgery was subsequently attempted on two occasions, but when invasion was found to have involved major vessels in the neck, further treatment had to be abandoned. Some lessons of the case are discussed.
Related Concept Videos
Cancer
What is Cancer?
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

