Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histamine and ascorbic acid in human blood

C A Clemetson

    The Journal of Nutrition
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Low ascorbic acid levels significantly increase blood histamine. Supplementing with ascorbic acid (vitamin C) effectively reduced histamine levels in volunteers, highlighting its role in histamine regulation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Influence of Environmental Temperature on Survival of Premature Animals.

    Canadian Medical Association journal·2010
    Same author

    The key role of histamine in the development of atherosclerosis and coronary heart disease.

    Medical hypotheses·1999
    Same author

    Abruptio placentae.

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·1981
    Same author

    Some thoughts on the epidemiology of cardiovascular disease, (with special reference to women "on the pill"). Role of ascorbic acid.

    Medical hypotheses·1979
    Same author

    Estrogens in food: the almond mystery.

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·1978
    Same author

    Secretion and reabsorption of uterine luminal fluid in rats.

    Journal of reproduction and fertility·1977

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Nutritional Science

    Background:

    • Ascorbic acid (vitamin C) is an essential nutrient involved in numerous biological processes.
    • Histamine is a biogenic amine with critical roles in immune responses and neurotransmission.
    • The relationship between ascorbic acid levels and histamine regulation in human blood requires further elucidation.

    Purpose of the Study:

    • To investigate the correlation between plasma-reduced ascorbic acid levels and whole blood histamine concentrations in humans.
    • To determine the threshold of ascorbic acid deficiency associated with significant histamine level increases.
    • To evaluate the efficacy of oral ascorbic acid supplementation in reducing elevated blood histamine levels.

    Main Methods:

    • Analysis of plasma-reduced ascorbic acid and whole blood histamine levels in 437 human blood samples.

    Related Experiment Videos

  • Statistical analysis to identify correlations and significant changes in histamine levels based on ascorbic acid concentrations.
  • Intervention study involving oral administration of 1 gram of ascorbic acid daily for 3 days to 11 volunteers.

    • Main Results:

    • A significant inverse correlation was observed: as plasma-reduced ascorbic acid levels decreased below 1 mg/100 ml, whole blood histamine levels increased exponentially.
    • A highly significant increase in blood histamine was noted when ascorbic acid levels dropped below 0.7 mg/100 ml.
    • All 11 volunteers who received oral ascorbic acid supplementation showed a reduction in their blood histamine levels.

    Conclusions:

    • Plasma-reduced ascorbic acid levels are critically linked to the regulation of whole blood histamine.
    • Ascorbic acid deficiency, particularly below 0.7 mg/100 ml, is associated with substantially elevated histamine levels.
    • Oral ascorbic acid supplementation is an effective strategy for reducing elevated blood histamine levels in humans.