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Folate compartments during gestational maturation

S Gross, B Kamen, A Fanaroff

    The Journal of Pediatrics
    |May 1, 1980
    PubMed
    Summary
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    Nearly 70% of total folate in infants is bound. This bound folate increases with gestational maturity, explaining folate loss during pregnancy and highlighting the need for active folate transport for metabolism.

    Area of Science:

    • Neonatal nutrition
    • Folate metabolism and transport

    Background:

    • Folate is essential for fetal development.
    • Understanding folate's form and transport is crucial for neonatal health.

    Purpose of the Study:

    • To investigate the prevalence of bound folate in preterm and term infants.
    • To correlate bound folate levels with gestational maturity and pregnancy.

    Main Methods:

    • Analysis of folate levels in 41 preterm and 53 term infants.
    • Utilized radioligand data to study folate biology.

    Main Results:

    • Approximately 70% of total folate was found in the bound form across infant groups.
    • Bound folate increased with gestational maturity, suggesting increased fetal demand.

    Related Experiment Videos

  • Observed a correlation between increased bound folate and folate loss during pregnancy.

    • Conclusions:

    • Folate is predominantly bound in infants, with levels increasing as gestation progresses.
    • Folate transport mechanisms are critical for meeting fetal demands and maintaining folate homeostasis.
    • Effective folate metabolism likely relies on metabolically active transport systems.