Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemically-induced transmissible abnormalities in sperm-head shape

J C Topham

    Mutation Research
    |March 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correspondence re: K. Hemminki et al., Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res., 56: 4374-4377, 1996.

    Cancer research·1997
    Same author

    Disturbance of macrophage and monocyte function in the dog by a thromboxane receptor antagonist: ICI 185,282.

    Toxicologic pathology·1995
    Same author

    Safety evaluation of meropenem in animals: studies on the kidney.

    The Journal of antimicrobial chemotherapy·1989
    Same author

    An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

    Mutation research·1983
    Same author

    An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

    Mutation research·1983
    Same author

    Sperm head abnormality test.

    Mutation research·1982
    Same journal

    Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

    Mutation research·2026
    Same journal

    Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

    Mutation research·2026
    Same journal

    IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

    Mutation research·2026
    Same journal

    Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

    Mutation research·2026
    Same journal

    The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

    Mutation research·2026
    Same journal

    E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

    Mutation research·2026
    See all related articles

    Genetic damage in mice can be measured by assessing abnormal sperm. This study quantines chemically-induced transmissible genetic damage in mouse sperm head shape.

    Area of Science:

    • Genetics and reproductive biology
    • Toxicology and mutagenesis

    Background:

    • Sperm head shape is determined by autosomal genes.
    • Genetic alterations in offspring can be quantified.
    • Sperm morphology is a sensitive indicator of genetic damage.

    Purpose of the Study:

    • To measure chemically-induced transmissible genetic damage in mice.
    • To assess the impact of mutagens on sperm head shape.
    • To establish a method for evaluating heritable genetic damage.

    Main Methods:

    • CBA mice (either sex) were treated with chemical mutagens.
    • Treated mice were mated with BALB/C mice.
    • Progeny sperm were analyzed for abnormal head shape incidence.

    Main Results:

    Related Experiment Videos

    • The incidence of abnormal sperm in progeny reflects genetic damage in parents.
    • Sperm head shape abnormalities serve as a quantifiable marker for genetic damage.
    • This method effectively measures transmissible genetic damage.

    Conclusions:

    • Autosomal genes control sperm head shape characteristics.
    • Chemically-induced genetic damage in mice can be effectively measured via sperm morphology analysis.
    • This approach provides a reliable method for assessing heritable genotoxicity.