Reproductive problems in the DES-exposed female

The records of 25 diethylstilbestrol-exposed women under treatment for reproductive dysfunction were reviewed. A tendency toward pregnancy wastage (5 of 10 patients), ectopic pregnancy (2 of 8 patients), cervical factor infertility (15 of 20 patients), hysterographic abnormalities (15 of 19 patients), and ovulatory dysfunction (10 of 25 patients) was noted. With the exceptions of ovulation induction and cervical cerclage, no means of treatment can be recommended.