Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reproductive problems in the DES-exposed female

D L Rosenfeld, R A Bronson

    Obstetrics and Gynecology
    |April 1, 1980
    PubMed
    Summary

    Diethylstilbestrol (DES) exposure in women is linked to reproductive issues. DES-exposed women show higher rates of pregnancy loss, ectopic pregnancy, infertility, and ovulatory dysfunction, with limited treatment options.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Topography of cerebral white-matter disease of prematurity studied prospectively in 1607 very-low-birthweight infants.

    Journal of child neurology·2001
    Same author

    Uterus didelphys with obstructed hemivagina and ipsilateral renal agenesis. A case report.

    The Journal of reproductive medicine·2001
    Same author

    Antisperm antibodies: a critical evaluation and clinical guidelines.

    Journal of reproductive immunology·2000
    Same author

    Bilateral smooth-muscle tumors of the adrenals in a child with AIDS.

    Pediatric radiology·1999
    Same author

    Progesterone promotes the acrosome reaction in capacitated human spermatozoa as judged by flow cytometry and CD46 staining.

    Molecular human reproduction·1999
    Same author

    Evidence that a functional fertilin-like ADAM plays a role in human sperm-oolemmal interactions.

    Molecular human reproduction·1999

    Area of Science:

    • Reproductive Medicine
    • Endocrinology
    • Obstetrics & Gynecology

    Background:

    • Diethylstilbestrol (DES) is a synthetic estrogen previously prescribed to prevent pregnancy complications.
    • DES exposure in utero has been associated with adverse reproductive outcomes in offspring.
    • Understanding the long-term reproductive effects of DES exposure is crucial for patient management.

    Purpose of the Study:

    • To review the reproductive dysfunction in women exposed to diethylstilbestrol (DES).
    • To identify specific reproductive abnormalities and their prevalence in DES-exposed women.
    • To evaluate the efficacy of current treatment modalities for DES-related reproductive dysfunction.

    Main Methods:

    • Retrospective review of medical records.
    • Analysis of reproductive history and outcomes in 25 DES-exposed women.
    • Assessment of infertility factors, pregnancy wastage, and hysterographic findings.

    Main Results:

    • High rates of pregnancy wastage (50%) and ectopic pregnancy (25%) were observed.
    • Cervical factor infertility (75%) and hysterographic abnormalities (79%) were prevalent.
    • Ovulatory dysfunction affected 40% of patients.

    Conclusions:

    • Diethylstilbestrol exposure is associated with significant reproductive dysfunction.
    • Limited treatment options exist, with ovulation induction and cervical cerclage showing some utility.
    • Further research is needed to develop effective treatments for DES-related reproductive issues.

    Related Experiment Videos