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Updated: Jul 22, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
[Experimental study on cattle anemia due to immune antibodies. 3. Effects of anemia on the liver]
Abstract:
A characterisation in greater detail was undertaken of haemolytic anaemia caused by immune antibody and its effects on the liver of young cattle. Bioptate follow-up tests were applied to two animals, while bromosulphalein half-life and SGOT activity were determined in seven. Centrolobular liver necrosis was not reproducible. Some moderate liver cell damage was histologically detected. Certain responses recorded from the reticulohistiocytary part of the liver were interpreted as a consequence of aggravated damage to erythrocytes. The above moderate liver cell damage failed to produce statistically secured rises in bromosulphalein half-life nor SGOT activity.
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