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Hemodynamic actions of pentagastrin
Scandinavian Journal of Gastroenterology
|January 1, 1980
Summary
Pentagastrin significantly boosts gastric and pancreatic blood flow in dogs without affecting overall circulation. This effect is linked to reduced resistance in splanchnic blood vessels.
Area of Science:
- Gastroenterology
- Pharmacology
- Hemodynamics
Background:
- Pentagastrin stimulates gastric acid secretion.
- Gastric acid secretion correlates with gastric blood flow.
Purpose of the Study:
- Investigate the hemodynamic effects of pentagastrin.
- Quantify pentagastrin's impact on blood flow in specific organs.
Main Methods:
- Anesthetized mongrel dogs were used.
- Intravenous pentagastrin administered logarithmically (1 ng to 8192 ng/kg).
- Blood flow measured using electromagnetic flow probes.
Main Results:
- Pentagastrin dose-dependently increased splanchnic blood flow in a reversed U-shape.
- Gastric and pancreatico-duodenal blood flow increased by 300% and 350% respectively at 2-4 microgram/kg.
- No significant changes in heart rate, cardiac output, or arterial pressure observed.
Conclusions:
- Pentagastrin has no general hemodynamic effect.
- Increased splanchnic blood flow is attributed to decreased splanchnic vascular resistance.
- Pentagastrin exhibits significant localized vasoactivity in the gastric and pancreatico-duodenal areas.