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Genetic expression of Wilson's disease in cell culture: a diagnostic marker
Science (New York, N.Y.)
|April 18, 1980
Abstract:
Wilson's disease fibroblasts have an elevated intracellular copper concentration as compared to cultured control cells. A decreased ratio of copper to protein was observed in cytoplasmic protein (or proteins) having a molecular weight greater than or equal to 30,000 in Wilson's disease cells. The results of this culture study indicate its potential importance in the early unequivocal diagnosis of this disorder.