Sinus histiocytosis with massive lymphadenopathy. A case report

A case of sinus histiocytosis is reported. This apparently rare disease was first described in 1969. The patient presented with a large, painless, bilateral cervical adenopathy which regressed completely over a 16-month period. Histological examination of a lymph node specimen showed sinuses distended with foamy histiocytes. Intervening lymphoid tissue showed a tremendous increase in plasma cells which distorted the normal architecture of the lymph node. The importance of accurate pathological diagnosis is again noted.