[Effect of excess-protein rations on natural immunity indices]

Some parameters of natural immunity under conditions of the diets with optimal (18%) and excessive (28,33 and 43% by caloric value) protein content were studied in male Wistar rats. It was shown that a number of the parameters studied (the content of complement, lysozyme, beta-lysines, the normal antibody titer, phagocytic activity of leukocytes, skin bactericidal action) decreased with the elevation of the protein content in the diets 3 months after the beginning of the experiment. The bactericidal activity of the blood serum in all the animal groups remained unchanged. The animals kept on diets with 18 and 43% of protein for prolonged period of time were examined 6, 9 and 12 months after the beginning of the experiment. The parameters of natural immunity (except the content of complement and beta-lysines) in the group of animals receiving 43% of protein remained decreased as compared with the control.