[Hypersensitivity to acetysal in bronchial asthma]

The incidence and clinical characteristics of hypersensitivity to acetysal were followed up in 529 patients with bronchial asthma. Manifestation of acetysal hypersensitivity was found in 46 patients (8.69%). It was manifested with bronchospasm in 78.25 per cent of the cases, in 23.91 per cent it was accompanied by skin alterations. Individuaal skin alterations were found in 21.73 per cent of the asthmatic patients with acetysal hypersensitivity. No allergic shock manifestations were observed. In 97.76 per cent of the patients with bronchial asthma and hypersensitivity to acetysal, hypersensitivity to some other medicaments was also found: analgin, analgesics of phenylbutazolon group (butadion, rheopyrin), indomethazin, antibiotics.