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[Hypersensitivity to acetysal in bronchial asthma]

G Kosturkov, M Staneva-Stoianova, Zh Mileva

    Vutreshni Bolesti
    |January 1, 1980
    PubMed
    Summary

    Hypersensitivity to acetysal (a nonsteroidal anti-inflammatory drug) affects 8.69% of asthma patients, often causing bronchospasm and skin issues. Many also react to other medications.

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    Area of Science:

    • Pharmacology
    • Pulmonology
    • Allergology

    Context:

    • Investigated hypersensitivity reactions to acetysal in a cohort of 529 patients diagnosed with bronchial asthma.
    • Assessed the clinical presentation and incidence of acetysal hypersensitivity within this patient group.

    Purpose:

    • To determine the prevalence of acetysal hypersensitivity in patients with bronchial asthma.
    • To characterize the clinical manifestations, including respiratory and dermatological symptoms, associated with acetysal hypersensitivity.
    • To identify co-existing hypersensitivity to other common medications in affected individuals.

    Summary:

    • Acetysal hypersensitivity was identified in 46 out of 529 asthma patients (8.69%).
    • The primary manifestation was bronchospasm (78.25%), followed by skin alterations (23.91% with general alterations, 21.73% with individual skin changes).
    • No instances of allergic shock were recorded. A significant comorbidity of hypersensitivity to other drugs (analgin, phenylbutazone group, indomethacin, antibiotics) was observed in 97.76% of cases.

    Impact:

    • Highlights the significant prevalence of acetysal hypersensitivity in asthma patients, emphasizing the need for careful medication selection.
    • Provides crucial data on the clinical spectrum of acetysal-induced reactions in asthmatics, aiding in differential diagnosis.
    • Underscores the high rate of cross-reactivity, suggesting a need for comprehensive allergy profiling in patients with suspected drug hypersensitivity.

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