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Enteric coated quinidine compared to sustained release preparations during repeated administration

O M Bakke, L Aanderud, A Aslaksen

    Acta Medica Scandinavica
    |January 1, 1980
    PubMed
    Summary

    Enteric-coated quinidine tablets (Systodin) provide stable plasma levels comparable to sustained-release formulations, offering a reliable option for maintenance therapy with good bioavailability.

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    Area of Science:

    • Pharmacokinetics
    • Drug formulation
    • Clinical pharmacology

    Background:

    • Quinidine is an antiarrhythmic drug requiring careful dosing for efficacy and safety.
    • Optimizing quinidine delivery systems is crucial for stable plasma concentrations during maintenance therapy.

    Purpose of the Study:

    • To compare the plasma concentration profiles and bioavailability of different quinidine formulations.
    • To evaluate the suitability of enteric-coated and sustained-release quinidine for maintenance therapy.

    Main Methods:

    • Plasma quinidine concentrations were measured in healthy subjects after multiple administrations of enteric-coated (Systodin) and sustained-release (Kinidin Duretter, Kinilentin) formulations.
    • Relative bioavailability was assessed by comparing these formulations to plain quinidine sulphate tablets using plasma concentration-time data (AUC12h).

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    Main Results:

    • Enteric-coated tablets (Systodin) and plain tablets yielded the largest area under the plasma concentration-time curve (AUC12h).
    • Plasma concentration variability was similar between enteric-coated tablets and sustained-release preparations.
    • Bioavailability of Systodin and Kinidin Duretter relative to plain tablets was 96% and 84%, respectively.

    Conclusions:

    • Enteric coating provides delayed absorption and stable quinidine plasma levels, suitable for maintenance therapy.
    • Enteric coating is a simple and reliable method for achieving therapeutic quinidine concentrations.
    • Systodin demonstrated comparable or superior performance to sustained-release formulations in maintaining stable quinidine levels.