Serum chromium in patients with recent and old myocardial infarction
Insights
Serum chromium levels did not differ in individuals with or without prior heart attacks. However, acute myocardial infarction significantly elevated serum chromium temporarily.
Area of Science:
- Cardiology
- Clinical Biochemistry
Background:
- Serum chromium levels are a potential biomarker in cardiovascular health.
- Previous studies have not established a clear link between chromium and ischemic heart disease.
Purpose of the Study:
- To investigate serum chromium levels in patients with and without ischemic heart disease.
- To determine if serum chromium levels change during acute myocardial infarction.
Main Methods:
- Serum chromium was measured in healthy subjects, patients with prior myocardial infarction, and patients with acute myocardial infarction.
- Levels were compared across groups and correlated with age, sex, and blood glucose.
Main Results:
- No significant difference in serum chromium was found between healthy individuals (1.71 ppb) and those with prior myocardial infarction (1.84 ppb).
- Serum chromium levels significantly increased (to 6.36 ppb) during the first five days of acute myocardial infarction, returning to baseline within ten days.
- No correlation was observed between serum chromium and blood glucose levels.
Conclusions:
- Serum chromium is not indicative of prior ischemic heart disease.
- Elevated serum chromium is a transient marker associated with acute myocardial infarction.
- Further research is needed to understand the role of chromium in acute cardiac events.
Abstract:
The serum chromium in 45 subjects with no clinical evidence of ischemic heart disease was found to be 1.71 parts per billion (ppb) (S.E. +/- 0.14). In 34 patients with a previously documented myocardial infarction, it was 1.84 ppb (S.E. +/- 0.18). The difference was not significant nor was there any difference with age or sex. In 37 patients with acute myocardial infarction the serum chromium level rose to a mean of 6.36 ppb (S.E. +/- 0.51; p less than 0.001) during the first five days following the infarct, returning to normal over the next five days. There was no correlation between the serum chromium and blood glucose levels in these patients or in a further 14 patients who were receiving glucose infusions (chest pain without electrocardiographic or enzyme changes) or who were diabetics.
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