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Related Experiment Videos

Acoustic reflex response during curare-induced weakness

R A Ruth, M E Johns, T F Gal

    The Annals of Otology, Rhinology, and Laryngology
    |March 1, 1980
    PubMed
    Summary

    The acoustic stapedial reflex (AR) is a sensitive indicator of neuromuscular transmission. Measuring the AR provides a reliable assessment of muscle strength, unaffected by patient effort.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • The acoustic stapedial reflex (AR) assesses the contraction of the stapedius muscle in response to sound.
    • Neuromuscular transmission can be compromised by various agents, necessitating reliable assessment methods.

    Purpose of the Study:

    • To evaluate the acoustic stapedial reflex (AR) as a sensitive index of neuromuscular blockade.
    • To compare the AR changes with respiratory muscle strength during d-tubocurarine administration.

    Main Methods:

    • The study involved five healthy subjects receiving intravenous d-tubocurarine in incremental doses.
    • Acoustic stapedial reflex amplitudes were measured using pulsed tones.
    • Maximum respiratory pressures were recorded to assess respiratory muscle strength.

    Main Results:

    • Progressive decreases in AR amplitude correlated with increasing doses of d-tubocurarine.
    • Expiratory muscle strength changes closely paralleled AR amplitude reductions.
    • Inspiratory muscle strength changes were less pronounced than AR changes, particularly in early stages of weakness.

    Conclusions:

    • The acoustic stapedial reflex (AR) is a valid and sensitive measure of neuromuscular transmission.
    • AR testing offers an advantage over manual muscle strength tests as it is independent of patient effort and cooperation.

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