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Connective tissue panniculitis

R K Winkelmann, A Padilha-Goncalves

    Archives of Dermatology
    |March 1, 1980
    PubMed
    Summary

    This study describes a rare connective tissue panniculitis in two patients, characterized by chronic lesions and specific antibodies. The condition responded well to antimalarial drugs, suggesting a link to autoimmune connective tissue diseases.

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    Involutional lipoatrophy: macrophage-related involution of fat lobules.

    Dermatology (Basel, Switzerland)·1995

    Area of Science:

    • Dermatology
    • Immunology
    • Rheumatology

    Background:

    • Panniculitis, inflammation of subcutaneous fat, can manifest in various forms.
    • Connective tissue diseases often involve systemic autoimmune processes affecting the skin.

    Observation:

    • Two patients presented with chronic lesions causing subcutaneous atrophy.
    • Histopathology revealed massive lymphocytic infiltrate and caseation necrosis of fat lobules.

    Findings:

    • Both patients exhibited unusual antibodies to extractable nuclear antigen, with occasional antinuclear antibody presence.
    • The panniculitis showed responsiveness to antimalarial drug therapy.

    Implications:

    • The distinct clinical, serologic, and therapeutic features suggest a unique entity, termed "connective tissue panniculitis."
    • This condition appears related to, but distinct from, lupus erythematosus panniculitis and subcutaneous morphea.

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