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Chronic hemofiltration treatment

E Streicher, H Schneider, U Knödler

    Artificial Organs
    |February 1, 1980
    PubMed
    Summary
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    Chronic hemofiltration improved hypertension and polyneuropathy in most patients. Dialysis discomfort significantly reduced, but metabolic markers showed mixed results, indicating potential benefits and areas for monitoring.

    Area of Science:

    • Nephrology
    • Renal Replacement Therapy

    Background:

    • Chronic kidney disease patients often experience complications like resistant hypertension, dialysis discomfort, hypertriglyceridemia, and polyneuropathy.
    • Hemofiltration is an alternative renal replacement therapy to hemodialysis.

    Purpose of the Study:

    • To evaluate the efficacy of chronic post-dilution hemofiltration in patients with end-stage renal disease.
    • To assess improvements in specific patient-reported symptoms and biochemical parameters.

    Main Methods:

    • Fourteen patients previously on hemodialysis were treated with chronic hemofiltration three times weekly.
    • Post-dilution hemofiltration technique was employed for 3 to 27 months.
    • Clinical outcomes, fluid balance, and hormone levels were monitored.

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    Main Results:

    • Hypertension improved in 6/8 patients; dialysis discomfort resolved in all 5 patients.
    • Polyneuropathy improved in 6/7 patients; hypertriglyceridemia showed inconsistent changes.
    • Phosphate, BUN, creatinine, and uric acid increased; amino acid and protein loss was negligible.
    • Thyroid hormones (T3, T4, TSH) decreased, while PTH levels increased.

    Conclusions:

    • Chronic hemofiltration offers significant benefits for hypertension, dialysis discomfort, and polyneuropathy in ESRD patients.
    • Metabolic and hormonal changes require careful monitoring during hemofiltration therapy.