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Related Experiment Videos

Cefaclor levels in human aqueous humor

J L Axelrod, R S Kochman

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Cefaclor penetration into human aqueous humor was studied. Oral cefaclor doses achieved therapeutic levels against common bacteria, suggesting potential efficacy in ocular infections.

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    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Pharmacokinetics

    Background:

    • Bacterial eye infections require effective antibiotic penetration into ocular tissues.
    • Understanding cefaclor's pharmacokinetic profile in the eye is crucial for its clinical application.

    Purpose of the Study:

    • To determine the concentration of cefaclor in human aqueous humor after oral administration.
    • To assess if cefaclor achieves therapeutic levels against common ocular pathogens.

    Main Methods:

    • 39 patients undergoing cataract extraction received either 500-mg or 1-g oral doses of cefaclor.
    • Aqueous humor samples were collected at various time points post-administration.
    • Cefaclor concentrations were measured using validated analytical methods.

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    Main Results:

    • Following a 500-mg dose, mean aqueous humor cefaclor levels ranged from 0.17 to 0.27 microgram/mL between 1 and 4 hours.
    • After a 1-g dose, mean levels varied from 0.31 to 0.72 microgram/mL between 1 and 5 hours.
    • Achieved concentrations were consistently above the minimum inhibitory concentrations (MICs) for Streptococcus pneumoniae and Group A Streptococcus.

    Conclusions:

    • Oral cefaclor demonstrates significant penetration into the human aqueous humor.
    • The achieved concentrations support the potential therapeutic use of cefaclor for ocular infections caused by susceptible bacteria.