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Related Experiment Videos

Retinal studies at 446 torr in a hypobaric chamber

J R Sutton, G Coates, G W Gray

    Aviation, Space, and Environmental Medicine
    |April 1, 1980
    PubMed
    Summary

    This study found that 24-hour exposure to 446 torr hypoxia did not cause retinal hemorrhage or leakage, even with exercise. The hypoxia level was insufficient to induce these specific ocular effects.

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    Area of Science:

    • Ophthalmology
    • Aerospace Medicine
    • Physiology

    Background:

    • Acute mountain sickness (AMS) can cause symptoms like headache and nausea.
    • Pulmonary edema can occur at high altitudes due to hypoxia.
    • Retinal changes have been observed in some individuals exposed to high altitude.

    Purpose of the Study:

    • To investigate the occurrence of retinal hemorrhage and fluorescein leakage after prolonged decompression.
    • To assess the impact of hypoxia and exercise on retinal vasculature.
    • To determine if 24-hour exposure to 446 torr is a sufficient hypoxic stress to cause retinal changes.

    Main Methods:

    • Four subjects underwent 24 hours of decompression to 446 torr.
    • Retinal photography and fluorescein angiography were performed at rest and during maximal exercise.

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  • Subjects' symptoms and physiological responses (e.g., lung density) were monitored.

    • Main Results:

    • No retinal hemorrhages or fluorescein leakage were observed in any subject.
    • Subjects reported typical AMS symptoms.
    • Increased lung density, indicative of subclinical pulmonary edema, was noted.

    Conclusions:

    • 24-hour exposure to 446 torr hypoxia, even with maximal exercise, is insufficient to induce retinal hemorrhage or leakage.
    • The study suggests that this level of hypoxia does not significantly stress the retinal vasculature.
    • Further research may be needed to determine the threshold for hypoxia-induced retinal changes.