The effect of delipidated high density lipoprotein on human leukocyte sterol synthesis

Sterol synthesis is increased when whole human serum is added to leukocytes in buffer. Addition to the buffer of an equivalent amount of serum from which lipid has been extracted by organic solvent leads to a greater increase in synthesis. The addition of whole high density lipoprotein to buffer has little effect on sterol synthesis whereas addition of delipidated high density lipoprotein stimulates sterol synthesis. Delipidated high density lipoprotein may be responsible for the stimulation of sterol synthesis by delipidated serum.