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Constrictive effect of pancuronium on capacitance vessels

C Lee, E Yang, M Lippmann

    British Journal of Anaesthesia
    |March 1, 1980
    PubMed
    Summary

    Pancuronium, a neuromuscular blocker, may constrict blood vessels. This study found pancuronium increased extracorporeal reservoir volume, suggesting a potential effect on vascular tone during open-heart surgery.

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    Area of Science:

    • Cardiovascular Pharmacology
    • Anesthesiology
    • Surgical Physiology

    Background:

    • Neuromuscular blocking agents are used in surgery.
    • Vascular tone significantly impacts hemodynamics during cardiopulmonary bypass.
    • Understanding drug effects on vascular capacitance is crucial for patient management.

    Purpose of the Study:

    • To investigate the effects of pancuronium, metocurine, and tubocurarine on vascular tone.
    • To determine the impact of these agents on vascular capacitance during open-heart surgery.

    Main Methods:

    • A study involving 26 patients undergoing open-heart surgery under total cardiopulmonary bypass.
    • Administration of pancuronium (0.08 mg kg-1), metocurine (0.4 mg kg-1), and tubocurarine (0.4 mg kg-1).
    • Monitoring of arterial pressure and extracorporeal reservoir volume to assess vascular tone and capacity.

    Main Results:

    • Pancuronium administration led to a significant increase in extracorporeal reservoir volume (average 780 +/- 250 ml, P < 0.01).
    • This increase suggests a reduction in vascular capacity, primarily influenced by venous tone.
    • Metocurine and tubocurarine effects on reservoir volume were not specified in the abstract.

    Conclusions:

    • Pancuronium may cause constriction of capacitance vessels in humans under specific surgical conditions.
    • The findings highlight a potential hemodynamic consequence of pancuronium use during cardiopulmonary bypass.
    • Further research may be warranted to fully elucidate the vascular effects of pancuronium.

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