Comparative study of atropine and glycopyrrolate on suxamethonium-induced changes in cardiac rate and rhythm

The effectiveness of atropine and glycopyrrolate in the prophylaxis of suxamethonium-induced bradycardia was evaluated in a double-blind study of 56 patients. Three had clinically demonstrable bradycardia, all having received atropine. We conclude that glycopyrrolate offered adequate protection against cardiac effects of repeated doses of suxamethonium.