Related Experiment Videos
Complement-fixing hidden rheumatoid factor in children with benign rheumatoid nodules
Arthritis and Rheumatism
|November 1, 1978
Summary
Children with benign rheumatoid nodules (BRN) possess high levels of hidden rheumatoid factor (RF) in their blood. This finding suggests a potential link between hidden RF and the development of these nodules.
Area of Science:
- Rheumatology
- Immunology
Background:
- Benign rheumatoid nodules (BRN) are observed in children, often without overt clinical disease.
- Previous studies have shown limited serological abnormalities in children with BRN.
Observation:
- This study investigated four children diagnosed with BRN.
- A hemolytic assay was employed to detect rheumatoid factor (RF) in their serum.
Findings:
- High titers of hidden rheumatoid factor (RF), specifically 19S IgM RF, were detected in children with BRN after acid separation.
- The median hidden RF titer in BRN patients was significantly higher (1:362) compared to healthy and disease controls (1:7; P < 0.001).
- Results indicate the presence of active, complement-fixing 19S IgM RF in the serum of children with BRN.
Implications:
- The presence of hidden RF in BRN patients suggests immune complex formation (19S IgM-7S IgG).
- This immune complex deposition may contribute to small vessel vasculitis and the formation of rheumatoid nodules in children.
- Further research is warranted to confirm the pathogenic role of hidden RF in BRN.