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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
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Published on: June 29, 2016

[Specific complex formation study of human immunoglobulins of various classes with their antibodies]

N A Konstantinova, G E Akinshina, V V Lavrent'ev

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |February 1, 1980
    PubMed

    The process of specific complex formation of different human immunoglobulines M, G and A with IgG antibody against them was investigated by the thermistor method. It was shown that the rate and intensity of the process vary with the types of interacting immunoglobulines, and that they reach maximum for IgM. From the character of the curves obtained a judgement can be formed about the immunoglobulin type being synthesized at the given moment. Disturbance of the inner structure of immunoglobulin macromolecules, e.g. during heating, leads to changes in the mechanism of complex formation, it being important what particular component underwent denaturation.

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