[Hematopoietic stem cell migration and differentiation in autoimmune mice of varying ages]

Age-dependent migration and differentiation of hematopoietic stem cells was studied in autoimmune mice (NZB chi chi NZW) F(1) of different age. It was shown that the migration rate of stem cells in old (NZB X NZW) F(1) mice decreases. Despite the age the granulopoietic differentia of stem cells was inhibited in these mice. It is suggested that (NZB x NZW) F(1) mice have either an impaired development of T lymphocyte subpopulation affecting the granulopoietic differentiation of stem cells or a genetic defect of the granulopoietic progenitors (CFU(c)).