Delay in onset of heat-sensitivity in a methylcholanthrene-induced tumor

A delay in onset of heat-sensitivity was demonstrated for methylcholanthrene-induced tumors implanted in the footpad of BALB/cJ or CAF1/J female mice. A heat dose of 46.0 +/- 0.1 degrees C/10 min resulted in long-term cure for a majority of the mice heated on day 7 post-implantation but cured only 4% of those heated on day zero and non-heated on day 1 post-implantation. By comparison, all untreated controls grew tumors which never spontaneously regressed and were dead within 3 months post-implantation.