[Treatment of urinary urge incontinence with clenbuterol (author's transl)]

Ten female patients with motor and 16 with sensory urge incontinence were treated with clenbuterol, a beta 2-sympathicomimetic drug, over a period of at least 4 weeks with a dosage of 10 microgram t.i.d. Urodynamic volumes increased significantly in sensory urge incontinence during the first and maximal urinary urgency; the tonometric index clearly decreased. Autonomous detrusor contraction, characteristic of motor urge incontinence, could be decreased or suppressed by clenbuterol. Urodynamic pressure characteristics were equally reduced significantly at first and maximal urinary urgency. In comparison, treatment of pure stress incontinence in 9 female patients led to no changes of measurements even after two weeks.