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Scanning electron microscope study of herpes simplex virus experimental disciform keratitis
The British Journal of Ophthalmology
|December 1, 1978
Summary
Scanning electron microscopy differentiated disciform edema from progressive disciform keratitis. Edema showed intact endothelium with subtle changes, while keratitis exhibited massive endothelial destruction.
Area of Science:
- Ophthalmology
- Cell Biology
- Microscopy
Background:
- Disciform keratitis is a condition affecting the cornea.
- Understanding endothelial changes is crucial for diagnosis and treatment.
Purpose of the Study:
- To differentiate disciform edema from progressive disciform keratitis using scanning electron microscopy.
- To characterize corneal endothelial morphology in these conditions.
Main Methods:
- Scanning electron microscopy (SEM) was used.
- Corneal endothelium from experimental disciform keratitis models was analyzed.
Main Results:
- Disciform edema cases showed an intact endothelium with subtle morphological alterations.
- Progressive disciform keratitis stages presented with massive endothelial destruction and denudation.
- Distinct endothelial patterns were observed between disciform edema and advanced keratitis.
Conclusions:
- SEM can distinguish between disciform edema and progressive disciform keratitis based on endothelial morphology.
- Endothelial integrity is preserved in disciform edema but compromised in advanced keratitis.