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Circulating iodothyronines in juvenile diabetic outpatients
Diabete & Metabolisme
|March 1, 1980
Summary
In juvenile diabetes, poor metabolic control significantly lowers serum triiodothyronine (T3) levels. However, serum T3 is not a sensitive indicator for moderate metabolic derangements in diabetic patients.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Diabetes Mellitus
Background:
- Thyroid hormone levels can be affected by metabolic status.
- Diabetes mellitus is a significant metabolic disorder with potential endocrine implications.
Purpose of the Study:
- To investigate the impact of varying metabolic control in juvenile diabetes on thyroid hormone levels.
- To compare serum concentrations of triiodothyronine (T3), reverse triiodothyronine (rT3), thyroxine (T4), and thyroid-stimulating hormone (TSH) between healthy subjects and diabetic patients with different glycemic control.
Main Methods:
- Measurement of serum T3, rT3, T4, and TSH.
- Inclusion of three groups: healthy subjects, juvenile diabetics in fair metabolic control, and juvenile diabetics in poor metabolic control (without ketonuria).
Main Results:
- Serum T3 levels were similar in healthy subjects and diabetics with fair metabolic control.
- Diabetics with poor metabolic control exhibited a 13.0% decrease in serum T3 compared to healthy subjects (p < 0.05).
- No significant differences were observed in serum rT3, T4, or TSH levels across the groups.
Conclusions:
- Metabolic derangement in diabetic patients affects serum T3 levels more readily than serum rT3.
- Serum T3 alterations are not a sensitive marker for detecting moderate metabolic derangements in juvenile diabetes.