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[The use of allopurinol in long-term treatments for optimal effect]
Fortschritte Der Medizin
|March 13, 1980
Abstract:
The importance of allopurinol drug formulation is discussed regarding the relationship between allopurinol-oxipurinol pharmacokinetics and the mechanism of action. The oxipurinol plasma levels were simulated basing on a single dose regimen and an oxipurinol plasma half life of 14 hours. From these data it is evident, that during long term treatment of hyperuricemia and gout a sustained release allopurinol-formulation fulfills the requirement of adequately maintained oxipurinol plasma levels.