Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The chromosome changes in non-Burkitt lymphomas

B R Reeves, V L Pickup

    Human Genetics
    |January 1, 1980
    PubMed
    Summary

    Cytogenetic analysis of non-Burkitt lymphomas reveals non-random chromosomal changes, particularly involving chromosome 14. These structural abnormalities in chromosomes can correlate with tumor histopathology, offering insights into lymphoproliferative disorders.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cryptic deletions and inversions of chromosome 21 in a phenotypically normal infant with transient abnormal myelopoiesis: a molecular cytogenetic study.

    British journal of haematology·1998
    Same author

    Deletions of chromosome 21 restricted to the leukemic cells of children with Down syndrome and leukemia.

    Leukemia·1997
    Same author

    Haematological abnormalities in Shwachman-Diamond syndrome.

    British journal of haematology·1996
    Same author

    Kostmann's disease, recombinant HuG-CSF, monosomy 7 and MDS/AML.

    British journal of haematology·1995
    Same author

    Pediatric myelodysplasia: a study of 68 children and a new prognostic scoring system.

    Blood·1995
    Same author

    A case of acute megakaryoblastic leukaemia with t(X;6)(p11.21;q23) having an X chromosome breakpoint within a 450-Kb region which is also disrupted in two classes of solid tumours.

    Leukemia·1995

    Area of Science:

    • Cytogenetics
    • Oncology
    • Hematopathology

    Background:

    • Non-Burkitt lymphomas are a heterogeneous group of lymphoid malignancies.
    • Understanding the underlying genetic alterations is crucial for diagnosis and treatment.
    • Previous studies have suggested chromosomal abnormalities in lymphoproliferative disorders.

    Purpose of the Study:

    • To investigate the cytogenetic profile of non-Burkitt lymphomas.
    • To identify non-random chromosomal aberrations in these tumors.
    • To correlate chromosomal abnormalities with histopathological findings.

    Main Methods:

    • Cytogenetic analysis was performed on tumor samples from 26 patients with non-Burkitt lymphomas.
    • Numerical and structural chromosomal changes were identified.
    • A literature review was conducted to compare findings with existing data.

    Main Results:

    • Non-random involvement of specific chromosomes was observed in numerical and structural changes.
    • Chromosome structural abnormalities were sometimes correlated with tumor histopathology.
    • Structural changes of chromosome 14 were the most common aberrations in lymphoproliferative disorders, based on combined analysis.

    Conclusions:

    • Cytogenetic analysis is valuable for characterizing non-Burkitt lymphomas.
    • Chromosome 14 structural aberrations are frequently implicated in lymphoproliferative disorders.
    • Further research into specific chromosomal alterations may improve understanding and management of these lymphomas.

    Related Experiment Videos