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In vitro studies on the duration of action of dihydroergotamine
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|January 1, 1980
Abstract:
Changes in tension were monitored isometrically on spiral strips from canine saphenous and femoral veins. Dihydroergotamine elicited an increase in tension at threshold concentrations (about 0.1 ng/ml) which are in accordance with mean plasma levels found in vivo after single oral doses in dog and man. In addition, it was demonstrated that the dihydroergotamine-induced venoconstriction persisted for several hours even when the drug was eliminated from the bathing solution.