Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthyroidism due to excess thyrotropin secretion: follow-up studies

V Mihailovic, M S Feller, I A Kourides

    The Journal of Clinical Endocrinology and Metabolism
    |June 1, 1980
    PubMed
    Summary

    This study followed a hyperthyroidism patient with excessive thyroid-stimulating hormone (TSH) secretion. Despite treatment, TSH levels fluctuated, suggesting a persistent pituitary issue, though a definitive cause remains elusive.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ferrocene-containing tetrahydropyrazolopyrazolones: Antioxidant and antimicrobial activity.

    Journal of inorganic biochemistry·2018
    Same author

    Antioxidant activity of selected plant species; potential new sources of natural antioxidants.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2010
    Same author

    Towards the re-introduction of grass pea (Lathyrus sativus) in the West Balkan Countries: the case of Serbia and Srpska (Bosnia and Herzegovina).

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2010
    Same author

    [Blood replacement in severely injured patients].

    Acta chirurgica Iugoslavica·2010
    Same author

    Comparison of pegvisomant and long-acting octreotide in patients with acromegaly naïve to radiation and medical therapy.

    Journal of endocrinological investigation·2009
    Same author

    Osteoporosis: the hormone connection.

    Health news (Waltham, Mass.)·2002

    Area of Science:

    • Endocrinology
    • Thyroidology
    • Pituitary Disorders

    Background:

    • This study details long-term follow-up of a patient with hyperthyroidism caused by excessive thyroid-stimulating hormone (TSH) secretion.
    • The patient was primarily treated with methimazole, an antithyroid medication.

    Observation:

    • Discontinuation of methimazole consistently led to significant elevations in serum TSH, T4, and T3 concentrations.
    • Initial and subsequent tests showed TSH levels decreased with dexamethasone but did not respond to TRH (thyrotropin-releasing hormone).
    • Serum glycoprotein alpha-subunit and TSH-beta levels were normal, with specific responses to dexamethasone and gonadotropin-releasing hormone observed.

    Findings:

    • The patient exhibited consistent TSH secretory dynamics, characterized by suppression with dexamethasone and lack of response to TRH.

    Related Experiment Videos

  • No pituitary enlargement was observed over a 7-year follow-up period.
  • The underlying cause of excessive TSH secretion remains unidentified.

    • Implications:

    • The observed TSH secretory dynamics align with patterns seen in patients with TSH-secreting pituitary adenomas.
    • Further investigation is warranted to elucidate the etiology of this rare endocrine disorder.
    • Understanding these dynamics aids in diagnosing and managing complex cases of hyperthyroidism.