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Related Experiment Videos

Actinide transport across cell membranes

R A Bulman, R J Griffin

    Journal of Inorganic Biochemistry
    |January 1, 1980
    PubMed
    Summary

    Protactinium uptake in the liver significantly increases with elevated phospholipid levels. Phosphatidic acid aids protactinium extraction, suggesting its role in liver accumulation of this element.

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    Area of Science:

    • Radiochemistry
    • Toxicology
    • Biochemistry

    Background:

    • Protactinium uptake in normal liver tissue is minimal (≤3%).
    • Phospholipid levels in the liver can be experimentally elevated using thioacetamide.
    • Certain phospholipids influence the behavior of radioactive elements in biological systems.

    Purpose of the Study:

    • To investigate the mechanism of protactinium uptake in the liver.
    • To determine the role of specific phospholipids in protactinium accumulation.
    • To explore the potential of phosphatidylserine in regulating liver uptake of actinides.

    Main Methods:

    • Measuring protactinium uptake in rat liver after thioacetamide administration.
    • Assessing the extraction of protactinium into organic solvents by different phospholipids.
    • Comparing the interaction of protactinium with phosphatidic acid and phosphatidylserine.

    Main Results:

    • Thioacetamide administration increased liver protactinium uptake to 31%.
    • Phosphatidic acid, absent in normal liver, effectively extracted protactinium into organic solvents.
    • Phosphatidylserine, present in normal liver cell membranes, did not extract protactinium.

    Conclusions:

    • Elevated liver phospholipid levels, specifically phosphatidic acid, enhance protactinium uptake.
    • Phosphatidylserine may play a regulatory role in the liver uptake of protactinium and other actinides like plutonium, americium, and curium.

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