Related Experiment Video

Updated: Sep 18, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy

J Itskovitz, H Abramovici, J M Brandes

    The Journal of Reproductive Medicine
    |March 1, 1980
    PubMed

    Three pregnancies in which indomethacin was given for several days to arrest premature delivery ended in oligohydramnion, meconium and perinatal death. These findings, together with previous information from animal experimentation and experience in humans reported on in the literature, show that indomethacin, a prostaglandin synthetase inhibitor, may interfere with the normal uteroplacental circulation, amniotic fluid production, renal functions and neonatal cardiopulmonary adaptation. The possible hazards of indomethacin treatment during the third trimester of pregnancy are discussed.

    More Related Videos

    A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development08:50

    A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

    Published on: June 24, 2020

    Generation of the Early-Gestational Maternal Immune Activation Mouse Model to Assess Prenatal Inflammation on Neurodevelopment08:53

    Generation of the Early-Gestational Maternal Immune Activation Mouse Model to Assess Prenatal Inflammation on Neurodevelopment

    Published on: March 24, 2026

    Related Concept Videos

    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...