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Updated: Aug 11, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Chikungunya viral arthropathy: a clinical description
The Journal of Rheumatology
|March 1, 1980
Summary
Chikungunya virus infection causes severe acute arthritis. Joint pain, stiffness, and swelling can persist for months, indicating a prolonged inflammatory response in patients.
Area of Science:
- Medical Virology
- Rheumatology
- Infectious Diseases
Background:
- Chikungunya virus (CHIKV) is known to cause acute arthritis.
- Limited clinical descriptions exist for the chronic phases of CHIKV-induced arthritis.
Purpose of the Study:
- To provide a clinical description of the acute and chronic phases of chikungunya fever arthritis.
- To characterize the duration and severity of CHIKV-related joint symptoms.
Main Methods:
- Clinical case series of 20 patients with chikungunya fever.
- Assessment of acute and chronic arthritis symptoms including pain, stiffness, and swelling.
- Monitoring of acute phase reactants and serum complement levels.
Main Results:
- All patients experienced severe, incapacitating acute arthritis.
- Joint pain, stiffness, and swelling persisted for at least 4 months in most patients, with some cases lasting 16 months.
- Laboratory findings indicated an infective response during the acute phase, with some persistent abnormalities months later.
Conclusions:
- Chikungunya fever frequently leads to prolonged and severe arthritis.
- Persistent joint symptoms and laboratory abnormalities suggest a lasting inflammatory process post-CHIKV infection.
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