[Therapeutic effect of oral doxycycline on syphilis (author's transl]

Eighty-one patients with syphilis were treated with oral doxycycline. A course of the antibiotic treatment consisted of 200 mg of doxycycline daily in two divided doses for 28 days. The course was repeated three to four times a year with an interval of several months. Quantitative Venereal Disease Research Laboratory (VDRL), Wassermann reaction (WR), and Treponema pallidum hemagglutination assay (TPHA) tests were performed monthly to evaluate the therapeutic effect of doxycycline treatment. The response rate was 100% for primary, 91.7% for early, 63.0% for late, and 61.8% for congenital syphilis in adults. No notable side effects were encountered except for epigastric fullness in four patients, which did not require the treatment to be discontinued. No abnormalities were detected in the results of laboratory tests.