[Extracellular fluid compartment in patients with a varying course of acute myocardial infarct]

It is shown that the main trend of changes in water homeostasis in complicated myocardial infarction consists in the development of intercellular hypohydration. Three variants of cardiogenic shock are distinguished: (a) normovolemic shock with intercellular hypohydration; (b) hypovolemic shock with intercellular hypohydration; (c) hypovolemic shock without intercellular hypohydration. Acute congestive cardiac insufficiency in most patients occurs without an increase in the volume of interstitial fluid. Approximately 12% of these patients have a reduced volume of circulating plasma. A syndrome of intercellular hyperhydration develops in the presence of satisfactory hemodynamics on the 3rd day after electrical defibrilation in individuals restored to life after clinical death. The VCP/VIF coefficient may serve as an index of the transcapillary flow of fluid and may be used in determining the indications for infusion therapy.