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[Leukocyte carboxylic esterases in healthy persons and in ischemic heart disease patients]

Iu P Nikitin, Z G Bondareva, D A Shakalis

    Kardiologiia
    |March 1, 1980
    PubMed

    Insights

    Esterase activity in blood leukocytes is significantly lower in patients with ischemic heart disease. This enzyme activity also shows reduced activation by heparin and adrenalin in older healthy individuals and those with heart disease.

    Area of Science:

    • Biochemistry
    • Cardiovascular Medicine
    • Hematology

    Background:

    • Atherosclerosis is a major cause of ischemic heart disease.
    • Leukocyte esterase activity may serve as a biomarker for cardiovascular health.

    Purpose of the Study:

    • To investigate esterase activity in blood leukocytes.
    • To compare enzyme activity between healthy individuals and patients with ischemic heart disease.
    • To assess the effect of age and disease on leukocyte esterase activation.

    Main Methods:

    • Studied 77 healthy individuals and patients with ischemic heart disease.
    • Measured blood leukocyte esterase activity.
    • Assessed enzyme activation using heparin and adrenalin.

    Main Results:

    • Significantly reduced esterase activity was observed in patients with ischemic heart disease.
    • Leukocyte esterase activation by heparin and adrenalin was diminished in older healthy individuals (45-65 years) and patients with ischemic heart disease compared to younger healthy individuals (20-30 years).

    Conclusions:

    • Reduced leukocyte esterase activity is associated with ischemic heart disease.
    • Age and ischemic heart disease impair leukocyte esterase response to stimuli like heparin and adrenalin.

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