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Gallstone dissolution with chenodeoxycholic acid. A clinical study

H J Weis, K H Holtermüller, P Gilsdorf

    Klinische Wochenschrift
    |March 17, 1980
    PubMed
    Summary
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    Chenodeoxycholic acid (CDC) effectively dissolves radiolucent gallstones smaller than 2 cm. A daily dose exceeding 13 mg/kg body weight yields over 60% success with minimal side effects.

    Area of Science:

    • Gastroenterology
    • Hepatology
    • Pharmacology

    Background:

    • Gallstones affect a significant portion of the population.
    • Surgical intervention carries risks and is not always preferred.
    • Medical dissolution offers a less invasive alternative for select patients.

    Purpose of the Study:

    • To evaluate the efficacy and safety of chenodeoxycholic acid (CDC) for gallstone dissolution.
    • To identify patient and treatment factors influencing successful gallstone dissolution.
    • To assess the impact of CDC on biliary colic and laboratory parameters.

    Main Methods:

    • A clinical study involving 95 patients with radiolucent gallstones treated with CDC for 12 months.
    • Gallstone dissolution assessed by a ≥30% reduction in area on X-rays.

    Related Experiment Videos

  • Analysis of patient demographics, gallstone size, CDC dosage (mg/kg/day), and laboratory values (aminotransferases, gamma-GT).

    • Main Results:

    • 40% of patients achieved gallstone dissolution (≥30% area reduction).
    • Gallstones >2 cm did not dissolve; success rate was 68% with CDC doses >13 mg/kg/day.
    • Diarrhea occurred in 31% but was manageable; biliary colic decreased; aminotransferases elevated in 20%.

    Conclusions:

    • Chenodeoxycholic acid is effective for dissolving radiolucent gallstones <2 cm.
    • Optimal treatment involves doses >13 mg/kg/day for improved success rates (>60%).
    • CDC therapy is associated with manageable side effects and reduced biliary colic incidence.