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["Atherosclerosis-index" (LDL/HDL): risk indicator in lipid metabolism disorders]
Insights
The atherosclerosis index, calculated from lipid levels, is the most reliable indicator of cardiovascular risk in hyperlipoproteinemia patients. Triglyceride levels showed the widest variation during the six to twelve-month follow-up.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Clinical Biochemistry
Context:
- Hyperlipoproteinemia management involves diet and lipid-lowering medications.
- Patient monitoring is crucial for assessing treatment efficacy and cardiovascular risk.
- Longitudinal studies are essential for understanding disease progression and treatment outcomes.
Purpose:
- To evaluate the reliability of various serum lipid coefficients as indicators of cardiovascular risk.
- To identify the most significant predictor of increased risk in patients with hyperlipoproteinemia.
- To assess the variability of lipid profiles during a six to twelve-month treatment period.
Summary:
- This study followed patients with hyperlipoproteinemia undergoing diet and drug therapy for six to twelve months.
- Serum concentrations of total cholesterol, triglycerides, phospholipids, HDL-cholesterol, and LDL-cholesterol were measured.
- The LDL/HDL ratio, termed the "atherosclerosis-index," emerged as the most dependable indicator of elevated cardiovascular risk (7.9 +/- 1.3%).
- Triglyceride concentrations exhibited the greatest variability (20.1 +/- 3.0%).
Impact:
- Identifies the "atherosclerosis-index" as a key biomarker for cardiovascular risk stratification in hyperlipoproteinemia.
- Provides insights into the variability of lipid parameters, aiding in treatment monitoring and adjustment.
- Contributes to a better understanding of lipid management strategies for reducing cardiovascular disease.
Abstract:
Patients with hyperlipoproteinemia, who were treated with diet and lipid-lowering drugs, were followed up over a period of six to twelve months. The various coefficients of serum concentrations of total cholesterol, triglycerides, phospholipids, HDL-cholesterol, LDL-cholesterol, and the ratio HDL-cholesterol/total cholesterol and LDL/HDL (socalled atherosclerosis-index) were estimated. Among all factors the "atherosclerosis-index" was the most reliable indicator of an increased risk with a margin of 7,9 +/- 1,3%. The widest variation was seen, as expected, among the concentrations of triglycerides (20,1 +/- 3,0%).